- Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease: A Preliminary Study
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Chang Soo Kim, Young Hee Sung, Min Ju Kang, Kee Hyung Park
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J Mov Disord. 2016;9(2):114-119. Published online March 2, 2016
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DOI: https://doi.org/10.14802/jmd.15039
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 Abstract
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- Objective
Rapid eye movement sleep behavior disorder (RBD) is associated with α-synucleinopathies, such as Parkinson’s disease (PD). We aimed to assess the differences in the clinical characteristics of PD with and without RBD.
Methods
Forty-two patients previously diagnosed with PD were evaluated for clinical history, motor and cognitive functioning using the Unified Parkinson’s Disease Rating Scale (UPDRS) and Mini-Mental State Examination (MMSE), autonomic symptoms, sleep characteristics using the Pittsburg Sleep Quality Index (PSQI), and the presence of RBD using the Korean version of the RBD screening questionnaire (RBDSQ). The prevalence of RBD and the patients’ demographic features were evaluated. The patients were classified into two groups, PD with RBD and PD without RBD, based on the RBDSQ scores. The motor and cognitive functions, as well as other clinical features of the two groups were compared.
Results
A total of 42 PD patients were enrolled. Eighteen patients were classified as PD with RBD. Compared to PD without RBD, PD with RBD showed higher scores of rigidity in the UPDRS subscale. Regarding sleep problems, PD with RBD revealed higher sleep disturbance, lower sleep efficiency, and lower overall sleep quality in the PSQI. There was no difference in cognitive dysfunction between the two groups according to the Korean version of the MMSE.
Conclusions
PD with RBD was associated with poorer sleep and motor symptoms. Therefore, RBD symptoms in PD are possibly poor prognostic markers.
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Citations
Citations to this article as recorded by  - Cerebellar Microstructural Abnormalities in Parkinson’s Disease: a Systematic Review of Diffusion Tensor Imaging Studies
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The Cerebellum.2022; 21(4): 545. CrossRef - A data-driven system to identify REM sleep behavior disorder and to predict its progression from the prodromal stage in Parkinson's disease
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Clinical Neurology and Neurosurgery.2021; 202: 106484. CrossRef - REM sleep behavior disorder portends poor prognosis in Parkinson’s disease: A systematic review
Yoon Kim, Young Eun Kim, Eun Ok Park, Chae Won Shin, Han-Joon Kim, Beomseok Jeon
Journal of Clinical Neuroscience.2018; 47: 6. CrossRef - Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis
Xiaona Zhang, Xiaoxuan Sun, Junhong Wang, Liou Tang, Anmu Xie
Neurological Sciences.2017; 38(1): 163. CrossRef - Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis
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Scientific Reports.2017;[Epub] CrossRef
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