- Immune-Mediated Cerebellar Ataxias: Clinical Diagnosis and Treatment Based on Immunological and Physiological Mechanisms
-
Hiroshi Mitoma, Mario Manto, Marios Hadjivassiliou
-
J Mov Disord. 2021;14(1):10-28. Published online January 12, 2021
-
DOI: https://doi.org/10.14802/jmd.20040
-
-
23,442
View
-
776
Download
-
29
Web of Science
-
35
Crossref
-
Abstract
PDF
- Since the first description of immune-mediated cerebellar ataxias (IMCAs) by Charcot in 1868, several milestones have been reached in our understanding of this group of neurological disorders. IMCAs have diverse etiologies, such as gluten ataxia, postinfectious cerebellitis, paraneoplastic cerebellar degeneration, opsoclonus myoclonus syndrome, anti-GAD ataxia, and primary autoimmune cerebellar ataxia. The cerebellum, a vulnerable autoimmune target of the nervous system, has remarkable capacities (collectively known as the cerebellar reserve, closely linked to plasticity) to compensate and restore function following various pathological insults. Therefore, good prognosis is expected when immune-mediated therapeutic interventions are delivered during early stages when the cerebellar reserve can be preserved. However, some types of IMCAs show poor responses to immunotherapies, even if such therapies are introduced at an early stage. Thus, further research is needed to enhance our understanding of the autoimmune mechanisms underlying IMCAs, as such research could potentially lead to the development of more effective immunotherapies. We underscore the need to pursue the identification of robust biomarkers.
-
Citations
Citations to this article as recorded by
- Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice
Dick Jaarsma, Maria B. Birkisdóttir, Randy van Vossen, Demi W.G.D. Oomen, Oussama Akhiyat, Wilbert P. Vermeij, Sebastiaan K.E. Koekkoek, Chris I. De Zeeuw, Laurens W.J. Bosman Neurobiology of Disease.2024; 192: 106422. CrossRef - Paraneoplastic Cerebellar Degeneration Associated with Breast Cancer: A Case Report and a Narrative Review
Rosario Luca Norrito, Maria Grazia Puleo, Chiara Pintus, Maria Grazia Basso, Giuliana Rizzo, Tiziana Di Chiara, Domenico Di Raimondo, Gaspare Parrinello, Antonino Tuttolomondo Brain Sciences.2024; 14(2): 176. CrossRef - Immune‐mediated spastic ataxia masquerading as clinically probable multisystem atrophy in an elderly woman
Rithvik Ramesh, Anuhya Chadalawada, Pedapati Radhakrishna, Lakshmi Narasimhan Ranganathan, Philo Hazeena, Sundar Shanmugam, Deepa Avadhani Clinical and Experimental Neuroimmunology.2024; 15(3): 146. CrossRef - Paraneoplastic neurological syndromes: upgraded approaches to diagnosis
V. N. Grigoryeva, E. A. Ruina Russian neurological journal.2024; 29(1): 4. CrossRef - Neuronal antibodies in nonparaneoplastic autoimmune cerebellar ataxias
Albert Saiz, Francesc Graus Current Opinion in Neurology.2024; 37(3): 322. CrossRef - Paraneoplastic Cerebellar Ataxia: A Case Report and Literature Review
静 刘 Advances in Clinical Medicine.2024; 14(03): 350. CrossRef - Autoantibodies related to ataxia and other central nervous system manifestations of gluten enteropathy
Tsvetelina Velikova, Georgi Vasilev, Russka Shumnalieva, Lyubomir Chervenkov, Dimitrina Georgieva Miteva, Milena Gulinac, Stamatios Priftis, Snezhina Lazova World Journal of Clinical Cases.2024; 12(12): 2031. CrossRef - Clinical Presentation, Management, and Diagnostic Performance of 2021 Criteria for Paraneoplastic Neurologic Syndromes in Childhood
Ji Zhou, Mei Jin, Yan Su, Xiuwei Zhuo, Libing Fu, Xiaotun Ren, Changhong Ren, Anna Zhou, Jiuwei Li, Weihua Zhang Neurology Neuroimmunology & Neuroinflammation.2024;[Epub] CrossRef - Recent advances in diagnosis of immune-mediated cerebellar ataxias: novel concepts and fundamental questions on autoimmune mechanisms
Hiroshi Mitoma, Mario Manto Journal of Neurology.2024;[Epub] CrossRef - Onconeural antibody-associated cerebellar ataxia: An analysis
Rohan Mahale, Sandeep M, Anitha Mahadevan, Nitish Kamble, Vikram Holla, Pramod K. Pal, Ravi Yadav Annals of Movement Disorders.2024; 7(2): 102. CrossRef - Autoimmunologische Kleinhirnerkrankungens
Niklas Vogel, Christian Hartmann, Sven Meuth, Nico Melzer Nervenheilkunde.2023; 42(01/02): 73. CrossRef - Evaluation and management of acute high-grade immunotherapy-related neurotoxicity
Marcelo Sandoval, Adriana H. Wechsler, Zahra Alhajji, Jayne Viets-Upchurch, Patricia Brock, Demis N. Lipe, Aisha Al-breiki, Sai-Ching J. Yeung Heliyon.2023; 9(3): e13725. CrossRef - Consensus Paper: Latent Autoimmune Cerebellar Ataxia (LACA)
Mario Manto, Marios Hadjivassiliou, José Fidel Baizabal-Carvallo, Christiane S Hampe, Jerome Honnorat, Bastien Joubert, Hiroshi Mitoma, Sergio Muñiz-Castrillo, Aasef G. Shaikh, Alberto Vogrig The Cerebellum.2023; 23(2): 838. CrossRef - Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia
Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zhu Pharmacological Research.2023; 191: 106773. CrossRef - Immune-related adverse events and immune checkpoint inhibitors: a focus on neurotoxicity and clinical management
Rosanna Ruggiero, Raffaella Di Napoli, Nunzia Balzano, Donatella Ruggiero, Consiglia Riccardi, Antonietta Anatriello, Andrea Cantone, Liberata Sportiello, Francesco Rossi, Annalisa Capuano Expert Review of Clinical Pharmacology.2023; 16(5): 423. CrossRef - Immune-mediated ataxias: Guide to clinicians
Alex T. Meira, Marianna P.M. de Moraes, Matheus G. Ferreira, Gustavo L. Franklin, Flávio M. Rezende Filho, Hélio A.G. Teive, Orlando G.P. Barsottini, José Luiz Pedroso Parkinsonism & Related Disorders.2023; 117: 105861. CrossRef - Gluten Ataxia: an Underdiagnosed Condition
Marios Hadjivassiliou, R. A. Grϋnewald The Cerebellum.2022; 21(4): 620. CrossRef - Clinical Problem Solving: Decreased Level of Consciousness and Unexplained Hydrocephalus
Naomi Niznick, Ronda Lun, Daniel A. Lelli, Tadeu A. Fantaneanu The Neurohospitalist.2022; 12(2): 312. CrossRef - Pharmacotherapy of cerebellar and vestibular disorders
João Lemos, Mario Manto Current Opinion in Neurology.2022; 35(1): 118. CrossRef - Advances in the Pathogenesis of Auto-antibody-Induced Cerebellar Synaptopathies
Hiroshi Mitoma, Mario Manto The Cerebellum.2022; 22(1): 129. CrossRef - A Breakdown of Immune Tolerance in the Cerebellum
Christiane S. Hampe, Hiroshi Mitoma Brain Sciences.2022; 12(3): 328. CrossRef - Acute Cerebellar Inflammation and Related Ataxia: Mechanisms and Pathophysiology
Md. Sorwer Alam Parvez, Gen Ohtsuki Brain Sciences.2022; 12(3): 367. CrossRef - A Case Report of Anti-PCA-2-Positive Autoimmune Cerebellitis
霞 董 Advances in Clinical Medicine.2022; 12(04): 3272. CrossRef - Cell-Autonomous Processes That Impair Xenograft Survival into the Cerebellum
Lorenzo Magrassi, Giulia Nato, Domenico Delia, Annalisa Buffo The Cerebellum.2022; 21(5): 821. CrossRef - Diagnosis and Clinical Features in Autoimmune-Mediated Movement Disorders
Pei-Chen Hsieh, Yih-Ru Wu Journal of Movement Disorders.2022; 15(2): 95. CrossRef - Autoimmune cerebellar ataxia associated with anti-leucine-rich glioma-inactivated protein 1 antibodies: Two pediatric cases
Zhang Weihua, Ren Haitao, Deng Jie, Ren Changhong, Zhou Ji, Zhou Anna, Guan Hongzhi, Ren Xiaotun Journal of Neuroimmunology.2022; 370: 577918. CrossRef - Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report
Jing Lin, Min Zhu, Xiaocheng Mao, Zeqing Jin, Meihong Zhou, Daojun Hong BMC Neurology.2022;[Epub] CrossRef - Central Positional Nystagmus
Ana Inês Martins, André Jorge, João Lemos Current Treatment Options in Neurology.2022; 24(10): 453. CrossRef - Paraneoplastic Ataxia: Antibodies at the Forefront Have Become Routine Biomarkers
Lazaros C. Triarhou, Mario Manto The Cerebellum.2022; 22(4): 534. CrossRef - Rare Etiologies in Immune-Mediated Cerebellar Ataxias: Diagnostic Challenges
Marios Hadjivassiliou, Mario Manto, Hiroshi Mitoma Brain Sciences.2022; 12(9): 1165. CrossRef - Paraneoplastic Syndromes in Neuro-Ophthalmology
Simon J. Hickman Annals of Indian Academy of Neurology.2022; 25(Suppl 2): S101. CrossRef - Immunotherapies for the Effective Treatment of Primary Autoimmune Cerebellar Ataxia: a Case Series
Jiao Li, Bo Deng, Wenli Song, Keru Li, Jingwen Ai, Xiaoni Liu, Haocheng Zhang, Yi Zhang, Ke Lin, Guofu Shao, Chunfeng Liu, Wenhong Zhang, Xiangjun Chen, Yanlin Zhang The Cerebellum.2022; 22(6): 1216. CrossRef - Evaluation and Management of Acute High-Grade Immunotherapy-Related Neurotoxicity
Marcelo Sandoval, Adriana H. Wechsler, Zahra Alhajji, Jayne Viets-Upchurch, Patricia A. Brock, Demis N. Lipe, Aisha Al-Buraiki, Sai-Ching Jim Yeung SSRN Electronic Journal .2022;[Epub] CrossRef - Stiff-Eye Syndrome—Anti-GAD Ataxia Presenting with Isolated Ophthalmoplegia: A Case Report
Abel Dantas Belém, Thaís de Maria Frota Vasconcelos, Rafael César dos Anjos de Paula, Francisco Bruno Santana da Costa, Pedro Gustavo Barros Rodrigues, Isabelle de Sousa Pereira, Paulo Roberto de Arruda Tavares, Gabriela Studart Galdino, Daniel Aguiar Dia Brain Sciences.2021; 11(7): 932. CrossRef - Update on Paraneoplastic Cerebellar Degeneration
Philipp Alexander Loehrer, Lara Zieger, Ole J. Simon Brain Sciences.2021; 11(11): 1414. CrossRef
|