Journal of Movement Disorders

Kuldeep Shetty

3 Articles

Myoclonus-Ataxia Syndrome Associated with COVID-19: Kuldeep Shetty, Atul Manchakrao Jadhav, Ranjith Jayanthakumar, Seema Jamwal, Tejaswini Shanubhogue, Mallepalli Prabhakar Reddy, Gopal Krishna Dash, Radhika Manohar, Vivek Jacob Philip, Vikram Huded; J Mov Disord. 2021;14(2):153-156. Published online April 6, 2021; DOI: https://doi.org/10.14802/jmd.20106

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Neurological manifestations of coronavirus disease (COVID-19) have increasingly been reported since the onset of the pandemic. Herein, we report a relatively new presentation. A patient in the convalescence period following a febrile illness with lower respiratory tract infection (fever, myalgia, nonproductive cough) presented with generalized disabling myoclonus, which is phenotypically suggestive of brainstem origin, along with additional truncal cerebellar ataxia. His neurology work-ups, such as brain MRI, electroencephalography, serum autoimmune and paraneoplastic antibody testing, were normal. His CT chest scan revealed right lower lung infiltrates, and serological and other laboratory testing did not show evidence of active infection. COVID-19 titers turned out to be strongly positive, suggestive of post-COVID-19 lung sequelae. He responded partially to antimyoclonic drugs and fully to a course of steroids, suggesting a para- or postinfectious immune-mediated pathophysiology. Myoclonusataxia syndrome appears to be a neurological manifestation of COVID-19 infection, and knowledge regarding this phenomenon should be increased among clinicians for better patient care in a pandemic situation.

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A case of suspected autoimmune encephalopathy with involuntary movements and cognitive dysfunction post‐COVID‐19
Yosuke Tenpaku, Naoki Mabuchi, Takahiro Kawase, Hideki Oguro, Hiroshi Tatsumi, Masayuki Satoh
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Opsoclonus Myoclonus Ataxia Syndrome Due to SARS-CoV-2
Josef Finsterer, Fulvio A. Scorza
Neuro-Ophthalmology.2023; 47(1): 1. CrossRef
Myoclonus in patients with COVID‐19: Findings of autoantibodies against brain structures in cerebrospinal fluid
Isa Lindqvist, Janet L. Cunningham, Jan Mulder, Amalia Feresiadou, Elham Rostami, Johan Virhammar, Eva Kumlien
European Journal of Neurology.2023; 30(10): 3142. CrossRef
Temporal Changes in Brain Perfusion in a Patient with Myoclonus and Ataxia Syndrome Associated with COVID-19
Kenta Osawa, Atsuhiko Sugiyama, Akiyuki Uzawa, Shigeki Hirano, Tatsuya Yamamoto, Masahiko Nezu, Nobuyuki Araki, Hiroki Kano, Satoshi Kuwabara
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Post‐infectious cerebellar ataxia following COVID‐19 in a patient with epilepsy
Sidhartha Chattopadhyay, Judhajit Sengupta, Sagar Basu
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Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysis
Rizaldy Taslim Pinzon, Vincent Ongko Wijaya, Abraham Al Jody, Patrick Nalla Nunsio, Ranbebasa Bijak Buana
Journal of Infection and Public Health.2022; 15(8): 856. CrossRef
Anti-neuronal antibodies against brainstem antigens are associated with COVID-19
Guglielmo Lucchese, Antje Vogelgesang, Fabian Boesl, Dina Raafat, Silva Holtfreter, Barbara M. Bröker, Angela Stufano, Robert Fleischmann, Harald Prüss, Christiana Franke, Agnes Flöel
eBioMedicine.2022; 83: 104211. CrossRef
Post–COVID‐19 Myoclonus–Ataxia Syndrome Responsive to Intravenous Immunoglobulins
Massimiliano Godani, Alessandro Beronio, Giuseppe Lanza
Movement Disorders Clinical Practice.2022;[Epub] CrossRef
Spectrum of de novo movement disorders in the setting of COVID-19 infection
Mitesh Chandarana, Heli Shah, Soaham Desai
Annals of Movement Disorders.2022; 5(1): 23. CrossRef
Anti-GAD associated post-infectious cerebellitis after COVID-19 infection
Ahmed Serkan Emekli, Asuman Parlak, Nejla Yılmaz Göcen, Murat Kürtüncü
Neurological Sciences.2021; 42(10): 3995. CrossRef

Recurrent ADCY5 Mutation in Mosaic Form with Nocturnal Paroxysmal Dyskinesias and Video Electroencephalography Documentation of Dramatic Response to Caffeine Treatment: Kuldeep Shetty, Asodu Sandeep Sarma, Meera Devan, Ashwin Dalal, Gopal Krishna Dash, Apuroopa Jannabhatla, Siddaramappa Jagadish Patil; J Mov Disord. 2020;13(3):238-240. Published online July 28, 2020; DOI: https://doi.org/10.14802/jmd.20014

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ADCY5-related dyskinesias: An amalgamation of various hyperkinetic movement disorders
Dinesh Khandelwal, Neha Pemassini, Ashish Pemawat, Vaibhav Mathur
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Scoping Review onADCY5‐Related Movement Disorders
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Awakening‐Related Bouts of Severe Opisthotonos in GNAO1
Alonso Zea Vera, Marc DiSabella, Laura Tochen, Meira Meltzer, Andrea Gropman
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Case report: Diagnosis of ADCY5-related dyskinesia explaining the entire phenotype in a patient with atypical citrullinemia type I
Audrey Pontrucher, Magalie Barth, Alban Ziegler, Juan Manuel Chao de la Barca, Delphine Mirebeau-Prunier, Pascal Reynier, Chadi Homedan
Frontiers in Neurology.2023;[Epub] CrossRef
ADCY5 Mutation-Movement Disorder with Sleep Disruption Improving with Caffeine
Neelu A Desai, David A Manchala, Neha I Patki
Neurology India.2022; 70(5): 2211. CrossRef
Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia
Martina Di Rocco, Serena Galosi, Enrico Lanza, Federica Tosato, Davide Caprini, Viola Folli, Jennifer Friedman, Gianfranco Bocchinfuso, Alberto Martire, Elia Di Schiavi, Vincenzo Leuzzi, Simone Martinelli
Human Molecular Genetics.2022; 31(6): 929. CrossRef
Efficacy of Caffeine in ADCY5‐Related Dyskinesia: A Retrospective Study
Aurélie Méneret, Shekeeb S. Mohammad, Laura Cif, Diane Doummar, Claudio DeGusmao, Mathieu Anheim, Magalie Barth, Philippe Damier, Nathalie Demonceau, Jennifer Friedman, Cécile Gallea, Domitille Gras, Juliana Gurgel‐Giannetti, Emily A. Innes, Ján Necpál, F
Movement Disorders.2022; 37(6): 1294. CrossRef
ADCY5-related dyskinesia: a case report
Shih-Ying Chen, Chen-Jui Ho, Yan-Ting Lu, Chih-Hsiang Lin, Meng-Han Tsai
Neurological Research and Practice.2022;[Epub] CrossRef
ADCY5-Related Dyskinesia in a Child with Sleep Related Paroxysmal Dyskinesia
Vikram V Holla, Koti Neeraja, Shweta Prasad, Nitish Kamble, Pramod Kumar Pal
The Indian Journal of Pediatrics.2021; 88(3): 308. CrossRef
Current challenges in the pathophysiology, diagnosis, and treatment of paroxysmal movement disorders
Cécile Delorme, Camille Giron, David Bendetowicz, Aurélie Méneret, Louise-Laure Mariani, Emmanuel Roze
Expert Review of Neurotherapeutics.2021; 21(1): 81. CrossRef
Treatable Hyperkinetic Movement Disorders Not to Be Missed
Aurélie Méneret, Béatrice Garcin, Solène Frismand, Annie Lannuzel, Louise-Laure Mariani, Emmanuel Roze
Frontiers in Neurology.2021;[Epub] CrossRef
ADCY5-related dyskinesia with myoclonus-dystonia syndrome
Udit Saraf, Mitesh Chandarana, K. P. Divya, Syam Krishnan
Annals of Movement Disorders.2021; 4(2): 86. CrossRef

Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease: Kuldeep Shetty, Syam Krishnan, Jissa Vinoda Thulaseedharan, Manju Mohan, Asha Kishore; J Mov Disord. 2019;12(2):84-90. Published online April 5, 2019; DOI: https://doi.org/10.14802/jmd.18048

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Abstract PDF

Objective
Recent reports of hearing impairment in Parkinson’s disease (PD) have suggested that auditory dysfunction could be a non-motor manifestation of PD. These reports were based on observations of elderly patients for whom presbycusis may, to some extent, have contributed to hearing dysfunction. Therefore, we aimed to explore the auditory functions in younger patients with PD. Methods We conducted a case-control study in a relatively younger (< 55 years of age at study time) population of PD patients and healthy volunteers to test whether auditory dysfunction is a significant non-motor dysfunction in PD. Pure tone audiometry (PTA) and brainstem evoked response audiometry (BERA) were performed in all participants. Results None of the patients or controls reported hearing deficits. Fifty-one patients with PD and 50 healthy volunteers who were age- and gender-matched to the patients participated. PTA-detected hearing impairment was found in 64.7% of patients and 28% of controls (p < 0.001) for both low-mid and/or high frequencies. Hearing impairment was more frequent in the younger subgroups of patients than age-matched controls, while the frequency of hearing impairment was similar in older groups of subjects. BERA was not different between patients and controls. Conclusion Asymptomatic auditory dysfunction is a common non-motor manifestation of early-onset PD and more frequent in younger patients, indicating that it may be independent of aging. The mechanism underlying this dysfunction appears to be peripheral, although a central dysfunction cannot be ruled out based on the findings of this study.

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Arquivos de Neuro-Psiquiatria.2025; 83(01): 001. CrossRef
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Büşra Kaynakoğlu, Mustafa Gokcan
Selçuk Sağlık Dergisi.2025; 6(1): 190. CrossRef
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Elena Garasto, Alessandro Stefani, Mariangela Pierantozzi, Matteo Conti, Arturo Moleti, Renata Sisto, Andrea Viziano, Claudio Liguori, Tommaso Schirinzi, Nicola Biagio Mercuri, Rocco Cerroni
Neurological Sciences.2024; 45(9): 4299. CrossRef
Relationship of Hearing Loss to Parkinson’s Disease, Dementia, and APOE Genotype in Adults
Chih-Hung Cha, Tsu-Kung Lin, Ching-Nung Wu, Chao-Hui Yang, Yi-Wen Huang, Chung-Feng Hwang
Medicina.2024; 60(5): 703. CrossRef
Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model
Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono, Satoru Kawamura, Eri Wakai, Tsuyoshi Miyoshi, Takashi Sato, Yumi Ohta, Takashi Saito, Takaomi C. Saido, Hidenori Inohara, Yoshikatsu Kanai, Hiroshi Hibino, Abdelwahab Omri
PLOS ONE.2024; 19(5): e0303375. CrossRef
Peripheral hearing in Parkinson’s disease: a systematic review
Mariana S. Leme, Seisse G. G. Sanches, Renata M. M. Carvallo
International Journal of Audiology.2023; 62(9): 805. CrossRef
(Zu-)Hören mit alterndem Gehirn – eine kognitive Herausforderung
Wilma Großmann
Laryngo-Rhino-Otologie.2023; 102(S 01): S12. CrossRef
Is Hearing Loss a Risk Factor for Idiopathic Parkinson’s Disease? An English Longitudinal Study of Ageing Analysis
Megan Rose Readman, Fang Wan, Ian Fairman, Sally A. Linkenauger, Trevor J. Crawford, Christopher J. Plack
Brain Sciences.2023; 13(8): 1196. CrossRef
Hearing Loss and Disorders: The Repercussions of Climate Change
Sue Sherratt
American Journal of Audiology.2023; 32(4): 793. CrossRef
Association between hearing sensitivity and dopamine transporter availability in Parkinson’s disease
Elena Garasto, Alessandro Stefani, Mariangela Pierantozzi, Rocco Cerroni, Matteo Conti, Simone Maranesi, Nicola B Mercuri, Agostino Chiaravalloti, Orazio Schillaci, Andrea Viziano, Arturo Moleti, Renata Sisto
Brain Communications.2023;[Epub] CrossRef
The Anatomy and Clinical Significance of Sensory Disturbance in Parkinson's Disease
Benxu Ma, Jianying Zhang, Yanlei Cui, Huanmin Gao
Journal of Integrative Neuroscience.2023;[Epub] CrossRef
Identifying Parkinson Risk Markers in Primary Care—Old Associations and New Insights
Bhavana Patel, Shannon Chiu, Melissa J. Armstrong
JAMA Neurology.2022; 79(4): 331. CrossRef
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JAMA Neurology.2022; 79(4): 359. CrossRef
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Journal of Comparative Neurology.2021; 529(5): 957. CrossRef
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Journal of Speech, Language, and Hearing Research.2021; 64(4): 1354. CrossRef
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Vasiliki Paplou, Nick M. A. Schubert, Sonja J. Pyott
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Auditory Dysfunction in Parkinson's Disease
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