Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders


Author index

Page Path
HOME > Browse Articles > Author index
Juha O Rinne 1 Article
Positron Emission Tomography in the Differential Diagnosis of Parkinsonism
Juha O Rinne
J Mov Disord. 2009;2(2):53-57.
  • 9,892 View
  • 72 Download
  • 2 Citations
AbstractAbstract PDF

Positron emission tomography (PET) studies on presynaptic dopaminergic function can reveal hypofunction in early Parkinson’s disease (PD) which may help in the early diagnosis especially in patients with mild symptoms. This hypofunction can be detected with fluorodopa (reflecting mainly aromatic amino acid decarboxylase activity of nigrostriatal terminals) or dopamine transporter ligands. These studies can also help to distinguish PD from essential tremor. However, investigations of presynaptic dopaminergic function are not useful in the differential diagnosis of parkinsonian syndromes. PET ligands, such as fluorodeoxyglucose (reflecting glucose metabolism) and dopamine receptor ligands, reflecting striatal neuronal function are better in this respect. Cardiac sympathetic function studies represent a new and interesting approach to improve differential diagnosis of parkinsonian syndromes but more studies are needed in larger patient populations with longer follow-up to evaluate the usefulness of these investigations. Multitracer approach combining ligands reflecting different aspects of dopaminergic neurotransmission and other physiological function will increase differential diagnostic accuracy.


Citations to this article as recorded by  
  • Hand Tremor Questionnaire: A Useful Screening Tool for Differentiating Patients with Hand Tremor between Parkinson's Disease and Essential Tremor
    Kyum-Yil Kwon, Ho-Sung Ryu, Hye Mi Lee, Mi-Jung Kim, Hae-Won Shin, Hee Kyung Park, Sooyeoun You, Young-Hee Sung, Sun Ju Chung, Seong-Beom Koh
    Journal of Clinical Neurology.2018; 14(3): 381.     CrossRef
  • Parkinsonian Patient with Comorbid Normal Pressure Hydrocephalus
    Jeong-Yoon Lee, Kayeong Im, Kyum-Yil Kwon
    Clinical Neuroradiology.2018; 28(4): 617.     CrossRef

JMD : Journal of Movement Disorders