Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Browse Articles > Author index
Search
Jiali Pu 1 Article
Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease
Xiaoli Si, Jiali Pu, Baorong Zhang
J Mov Disord. 2017;10(2):69-79.   Published online May 8, 2017
DOI: https://doi.org/10.14802/jmd.16061
  • 10,732 View
  • 351 Download
  • 11 Web of Science
  • 10 Crossref
AbstractAbstract PDF
Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy.

Citations

Citations to this article as recorded by  
  • Mitochondrial DNA Leakage and cGas/STING Pathway in Microglia: Crosstalk Between Neuroinflammation and Neurodegeneration
    Yuqian Liu, Bohan Zhang, Ruonan Duan, Yiming Liu
    Neuroscience.2024; 548: 1.     CrossRef
  • Positron Emission Tomography with [18F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy
    Evan Gallagher, Catherine Hou, Yi Zhu, Chia-Ju Hsieh, Hsiaoju Lee, Shihong Li, Kuiying Xu, Patrick Henderson, Rea Chroneos, Malkah Sheldon, Shaipreeah Riley, Kelvin C. Luk, Robert H. Mach, Meagan J. McManus
    International Journal of Molecular Sciences.2024; 25(9): 4943.     CrossRef
  • Navigating the Gene Co-Expression Network and Drug Repurposing Opportunities for Brain Disorders Associated with Neurocognitive Impairment
    Mathew Timothy Artuz Manuel, Lemmuel L. Tayo
    Brain Sciences.2023; 13(11): 1564.     CrossRef
  • Glymphatic Magnetic Resonance Imaging: Part II—Applications in Sleep and Neurodegenerative Diseases
    Hyochul Lee, Roh-Eul Yoo, Seung Hong Choi
    Investigative Magnetic Resonance Imaging.2023; 27(4): 208.     CrossRef
  • An Enlarged Perivascular Space: Clinical Relevance and the Role of Imaging in Aging and Neurologic Disorders
    Younghee Yim, Won-Jin Moon
    Journal of the Korean Society of Radiology.2022; 83(3): 538.     CrossRef
  • Studying the effect of alpha-synuclein and Parkinson’s disease linked mutants on inter pathway connectivities
    Sagnik Sen, Ashmita Dey, Ujjwal Maulik
    Scientific Reports.2021;[Epub]     CrossRef
  • A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration
    Zhan Zhao, Yubao Wang, Ran Zhou, Yi Li, Yun Gao, Dezhen Tu, Belinda Wilson, Sheng Song, Jing Feng, Jau-Shyong Hong, Jerrel L. Yakel
    Journal of Neuroinflammation.2020;[Epub]     CrossRef
  • Different Perivascular Space Burdens in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
    Xiao-li Si, Lu-yan Gu, Zhe Song, Cheng Zhou, Yi Fang, Chong-yao Jin, Jing-jing Wu, Ting Gao, Tao Guo, Xiao-jun Guan, Xiao-jun Xu, Xin-zhen Yin, Ya-ping Yan, Min-min Zhang, Jia-li Pu
    Frontiers in Aging Neuroscience.2020;[Epub]     CrossRef
  • Central Nervous System-Derived Exosomal Alpha-Synuclein in Serum May Be a Biomarker in Parkinson’s Disease
    Xiaoli Si, Jun Tian, Yanxing Chen, Yaping Yan, Jiali Pu, Baorong Zhang
    Neuroscience.2019; 413: 308.     CrossRef
  • Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration
    Duraisamy Kempuraj, Ramasamy Thangavel, Govindhasamy P. Selvakumar, Smita Zaheer, Mohammad E. Ahmed, Sudhanshu P. Raikwar, Haris Zahoor, Daniyal Saeed, Prashant A. Natteru, Shankar Iyer, Asgar Zaheer
    Frontiers in Cellular Neuroscience.2017;[Epub]     CrossRef

JMD : Journal of Movement Disorders Twitter