Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Browse Articles > Author index
Search
Jae Hyeok Lee 3 Articles
Current Status of Huntington’s Disease in Korea: A Nationwide Survey and National Registry Analysis
Hyun Sook Kim, Chul Hyoung Lyoo, Phil Hyu Lee, Sang Jin Kim, Mee Young Park, Hyeo-Il Ma, Jae Hyeok Lee, Sook Kun Song, Jong Sam Baik, Jin Ho Kim, Myung Sik Lee
J Mov Disord. 2015;8(1):14-20.   Published online January 31, 2015
DOI: https://doi.org/10.14802/jmd.14038
  • 15,528 View
  • 114 Download
  • 14 Citations
AbstractAbstract PDF
Objective Huntington’s disease (HD) is a rare neurological disorder, and its current status in Korea is not well investigated. This study aims to determine the prevalence and incidence of HD and to investigate the clinical features of HD patients in Korea.
Methods We estimated the crude prevalence and annual incidence of HD based on the databases of the Rare Diseases Registry (RDR) and the National Health Insurance (NHI). The clinical data of genetically confirmed HD patients was collected from 10 referral hospitals and analyzed.
Results The mean calculated annual incidence was 0.06 cases per 100,000 persons, and the mean calculated prevalence was 0.38 based on the NHI database. The estimated crude prevalence based on the RDR was 0.41. Of the sixty-eight HD patients recruited, the mean age of onset was 44.16 ± 14.08 years and chorea was most frequently reported as the initial symptom and chief complaint. The mean CAG repeat number of the expanded allele was 44.7 ± 4.8 and correlated inversely with the age of onset (p < 0.001). About two-thirds of the patients have a positive family history, and HD patients without positive family history showed a delay in onset of initial symptoms, a prolonged interval between initial symptom onset and genetic diagnosis and a delay in the age of genetic diagnosis.
Conclusions To the best of our knowledge, this is the first study to estimate the prevalence and incidence of HD in Korea and the largest HD series in the Asian population. Our analyses might be useful for further studies and large-scale investigations in HD patients.

Citations

Citations to this article as recorded by  
  • Epidemiology of Acute Leukemia among Children with Down Syndrome in Korea
    Young Bae Choi, Keon Hee Yoo
    Cancer Research and Treatment.2022; 54(2): 572.     CrossRef
  • Population Prevalence, Cancer Risk, and Mortality Risk of Turner Syndrome in South Korean Women Based on National Health Insurance Service Data
    Sung Eun Kim, Sang Hyun Park, Kyungdo Han, Won Kyoung Cho, Byung-Kyu Suh, Yong-Gyu Park
    Yonsei Medical Journal.2022; 63(11): 991.     CrossRef
  • Prevalence and Incidence of Huntington's Disease: An Updated Systematic Review and Meta‐Analysis
    Alex Medina, Yasamin Mahjoub, Larry Shaver, Tamara Pringsheim
    Movement Disorders.2022; 37(12): 2327.     CrossRef
  • Contemporary Status of Acute Myocardial Infarction in Korean Patients: Korean Registry of Acute Myocardial Infarction for Regional Cardiocerebrovascular Centers
    Rock Bum Kim, Jin Yong Hwang, Hyun Woong Park, Ae-Young Her, Jang Hoon Lee, Moo Hyun Kim, Chang Hwan Yoon, Jae Young Cho, Sung-Il Woo, Yongcheol Kim, Jae-Young Han, Joon Hyouk Choi, Song Yi Kim, Si Wan Choi, Sung Ju Jee, Sang Yeub Lee, Ki-Bum Won, Kyeong-
    Journal of Clinical Medicine.2021; 10(3): 498.     CrossRef
  • Huntington’s Disease in Israel: A Population-Based Study Using 20 Years of Routinely-Collected Healthcare Data
    Natalie Gavrielov-Yusim, Yael Barer, Michael Martinec, Athanasios Siadimas, Spyros Roumpanis, Hannah Furby, Inbal Goldshtein, Asif Jan, Preciosa M. Coloma
    Journal of Huntington's Disease.2021; 10(4): 469.     CrossRef
  • The Population Prevalence, Associations of Congenital Heart Defect and Mortality Risk for Down’s Syndrome in South Korea Based on National Health Insurance Service (NHIS) Data


    Won Kyoung Cho, Na Young Lee, Kyungdo Han, Byung-Kyu Suh, Yong-Gyu Park
    Clinical Epidemiology.2020; Volume 12: 519.     CrossRef
  • Incidence of Huntington disease in a northeastern Spanish region: a 13-year retrospective study at tertiary care centre
    Paula Sienes Bailo, Raquel Lahoz, Juan Pelegrín Sánchez Marín, Silvia Izquierdo Álvarez
    BMC Medical Genetics.2020;[Epub]     CrossRef
  • The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population
    Chris Kay, Jennifer A. Collins, Galen E.B. Wright, Fiona Baine, Zosia Miedzybrodzka, Folefac Aminkeng, Alicia J. Semaka, Cassandra McDonald, Mark Davidson, Steven J. Madore, Erynn S. Gordon, Norman P. Gerry, Mario Cornejo-Olivas, Ferdinando Squitieri, Sar
    American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.2018; 177(3): 346.     CrossRef
  • Quantitative Gait Analysis in Patients with Huntington’s Disease
    Seon Jong Pyo, Hanjun Kim, Il Soo Kim, Young-Min Park, Mi-Jung Kim, Hye Mi Lee, Seong-Beom Koh
    Journal of Movement Disorders.2017; 10(3): 140.     CrossRef
  • Epidemiological Study of Huntington's Disease in the Province of Ferrara, Italy
    Erika Carrassi, Maura Pugliatti, Vittorio Govoni, Mariachiara Sensi, Ilaria Casetta, Enrico Granieri
    Neuroepidemiology.2017; 49(1-2): 18.     CrossRef
  • The Epidemiology of Myasthenia Gravis in Korea
    Hyung Seok Lee, Hye Sun Lee, Ha Young Shin, Young-Chul Choi, Seung Min Kim
    Yonsei Medical Journal.2016; 57(2): 419.     CrossRef
  • The global prevalence of Huntington's disease: a systematic review and discussion
    Sheharyar Sajjad Baig, Mark Strong, Oliver WJ Quarrell
    Neurodegenerative Disease Management.2016; 6(4): 331.     CrossRef
  • Clinical and genetic characteristics in patients with Huntington’s disease from China
    Jing Yang, Ke Chen, Qianqian Wei, Yongping Chen, Bei Cao, Jean-Marc Burgunder, Hui-Fang Shang
    Neurological Research.2016; 38(10): 916.     CrossRef
  • Survival of Korean Huntington’s Disease Patients
    Han-Joon Kim, Chae-Won Shin, Beomseok Jeon, Hyeyoung Park
    Journal of Movement Disorders.2016; 9(3): 166.     CrossRef
Suppression of Myoclonus in Corticobasal Degeneration by Levetiracetam
Jae Wook Cho, Jae Hyeok Lee
J Mov Disord. 2014;7(1):28-30.   Published online April 30, 2014
DOI: https://doi.org/10.14802/jmd.14007
  • 9,241 View
  • 97 Download
  • 10 Citations
AbstractAbstract PDF
Myoclonus in corticobasal degeneration (CBD) has often been associated with severe and difficult to treat disabilities. Levetiracetam is a new antiepileptic agent with antimyoclonic effects. Herein, we present a 72-year-old woman with clinically probable CBD and with spontaneous rhythmic myoclonus in the right foot, which was markedly ameliorated through treatment with levetiracetam. The effect of levetiracetam was associated with the decreased amplitude of enlarged cortical somatosensory evoked potentials. This result suggests that the antimyoclonic effect of levetiracetam might be mediated through the suppression of increased cortical excitability.

Citations

Citations to this article as recorded by  
  • Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies
    Abdullahi Alausa, Sunday Ogundepo, Barakat Olaleke, Rofiat Adeyemi, Mercy Olatinwo, Aminat Ismail
    Chinese Medicine.2021;[Epub]     CrossRef
  • Four-Repeat Tauopathies: Current Management and Future Treatments
    Lawren VandeVrede, Peter A. Ljubenkov, Julio C. Rojas, Ariane E. Welch, Adam L. Boxer
    Neurotherapeutics.2020; 17(4): 1563.     CrossRef
  • Physiology-Based Treatment of Myoclonus
    Ashley B. Pena, John N. Caviness
    Neurotherapeutics.2020; 17(4): 1665.     CrossRef
  • Pharmacological interventions in corticobasal degeneration: a review
    Leonardo Caixeta, Victor de Melo Caixeta, Yanley Lucio Nogueira, Tales Alexandre Aversi-Ferreira
    Dementia & Neuropsychologia.2020; 14(3): 243.     CrossRef
  • Available and future treatments for atypical parkinsonism. A systematic review
    Davide Vito Moretti
    CNS Neuroscience & Therapeutics.2019; 25(2): 159.     CrossRef
  • An Update on Myoclonus Management
    Christine M. Stahl, Steven J. Frucht
    Expert Review of Neurotherapeutics.2019; 19(4): 325.     CrossRef
  • Corticobasal degeneration: key emerging issues
    F. Ali, K. A. Josephs
    Journal of Neurology.2018; 265(2): 439.     CrossRef
  • Focal Predominant Forms of Posthypoxic Action Myoclonus
    Carmen Gasca-Salas, Anthony E. Lang
    Movement Disorders Clinical Practice.2016; 3(4): 417.     CrossRef
  • Progressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options
    Ruth Lamb, Jonathan D. Rohrer, Andrew J. Lees, Huw R. Morris
    Current Treatment Options in Neurology.2016;[Epub]     CrossRef
  • An Update and Review of the Treatment of Myoclonus
    Kelly Mills, Zoltan Mari
    Current Neurology and Neuroscience Reports.2015;[Epub]     CrossRef
Oculogyric Crisis Associated with Disulfiram-Induced Pallidonigral Lesion
Jae Hyeok Lee, Chul Hyoung Lyoo, Jin Goo Lee, Myung Sik Lee
J Mov Disord. 2009;2(1):48-49.
DOI: https://doi.org/10.14802/jmd.09013
  • 8,376 View
  • 63 Download
AbstractAbstract PDF

We report a man who developed oculogyric crisis one month after disulfiram intoxication. Brain MRI showed lesions involving bilateral globus pallidus and left substantia nigra. In our patient, neuronal discharges from pathologically reorganized basal ganglia circuit to the mid-brain ocular motor center might lead to tonic deviation of the eyes.


JMD : Journal of Movement Disorders