- Effectiveness of Live-Streaming Tele-Exercise Intervention in Patients With Parkinson’s Disease: A Pilot Study
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Jongmok Ha, Jung Hyun Park, Jun Seok Lee, Hye Young Kim, Ji One Song, Jiwon Yoo, Jong Hyeon Ahn, Jinyoung Youn, Jin Whan Cho
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J Mov Disord. 2024;17(2):189-197. Published online February 29, 2024
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DOI: https://doi.org/10.14802/jmd.23251
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Abstract
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- Objective
Exercise can improve both motor and nonmotor symptoms in people with Parkinson’s disease (PwP), but there is an unmet need for accessible and sustainable exercise options. This study aimed to evaluate the effect, feasibility, and safety of a regularly performed live-streaming tele-exercise intervention for PwP.
Methods A live-streaming exercise intervention for PwP was implemented twice a week for 12 weeks. We measured the motor and nonmotor symptom scores of the included patients before and after the intervention. Changes in clinical scores from baseline to postintervention were analyzed using paired t-tests. Factors associated with improvements in clinical scores and compliance were analyzed using Pearson’s correlation analysis.
Results Fifty-six participants were enrolled in the study. There were significant improvements in Hospital Anxiety and Depression Scale (HADS)-anxiety (p = 0.007), HADS-depression (p < 0.001), Unified Parkinson’s Disease Rating Scale (UPDRS) part III (p < 0.001), UPDRS total (p = 0.015), Hoehn and Yahr stage (p = 0.027), and Parkinson’s Disease Fatigue Scale-16 (p = 0.026) scores after the intervention. Improvements in motor symptoms were associated with improvements in mood symptoms and fatigue. Higher motor impairment at baseline was associated with a greater compliance rate and better postintervention composite motor and nonmotor outcomes (ΔUPDRS total score). Overall, the 12-week tele-exercise program was feasible and safe for PwP. No adverse events were reported. The overall adherence rate was 60.0% in our cohort, and 83.4% of the participants were able to participate in more than half of the exercise routines.
Conclusion The live-streaming tele-exercise intervention is a safe, feasible, and effective nonpharmacological treatment option that can alleviate fatigue and improve mood and motor symptoms in PwP.
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Citations
Citations to this article as recorded by 
- Relationship between stigma and negative emotions among patients with Parkinson’s disease: The mediating role of health literacy and family function
Aoxue Zhu, Huiling Xie, Juan Wei, Mei Wang, Tianrong Huang, Huina Mao Geriatric Nursing.2025; 63: 567. CrossRef - Feasibility and preliminary efficacy of an online home-based functional exercise program for Parkinson's disease: a pilot study
Hyungwoo Lee, Hunyoung Ha, Heehyun Shin, Byungjun Park, Nyeonju Kang, Kiwon Park, Ryul Kim, Kyeongho Byun Frontiers in Neurology.2025;[Epub] CrossRef
- Factors Associated with Medication Beliefs in Patients with Parkinson’s Disease: A Cross-Sectional Study
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Sung Reul Kim, Ji Young Kim, Hye Young Kim, Hui Young So, Sun Ju Chung
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J Mov Disord. 2021;14(2):133-143. Published online May 3, 2021
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DOI: https://doi.org/10.14802/jmd.20147
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8,568
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152
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7
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6
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Abstract
PDF Supplementary Material
- Objective
Medication beliefs are a significant determinant of medication adherence in chronic illness. This study aimed to identify demographic, clinical, and medication-related factors associated with medication beliefs in patients with Parkinson’s disease (PD).
Methods
We used a descriptive cross-sectional design with a convenience sample of 173 PD patients who had been taking antiparkinson drugs for more than one year.
Results
The subjects who believed PD medication was more necessary had more severe illness, younger age of onset, longer illness duration, and longer duration of levodopa therapy. They had higher levels of non-motor symptoms and depression, number of medication uses, number of drugs, and levodopa equivalent dose, and they reported fluctuation of motor symptoms and dyskinesia. The subjects who used catechol-O-methyltransferase (COMT) inhibitors, dopamine agonists, amantadine, and monoamine oxidase-B (MAO-B) inhibitors had significantly higher necessity scores than those who did not use them. The subjects who had higher concerns about PD medications had higher levels of non-motor symptoms and depression. The subjects using amantadine and anticholinergics had significantly higher concern scores than those who did not use them. Positive necessity-concerns differentials were associated with severe illness, the presence of motor fluctuation and dyskinesia, and the use of COMT inhibitors. Based on stepwise multiple regression, the most significant factors influencing necessity beliefs were severe illness, followed by depression and motor fluctuation.
Conclusion
Severe illness, higher levels of depression, and motor fluctuation are independent factors influencing patients’ beliefs regarding medication necessity. Therefore, these characteristics should be considered in medication belief assessment and interventions for PD patients.
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Citations
Citations to this article as recorded by 
- Clinical Clusters for Identification of Lower Adherence in Patients with Parkinson’s Disease: A Cross-Sectional Study
Igor Straka, Michal Minár, Veronika Boleková, Matej Škorvánek, Milan Grofik, Katarína Danterová, Ján Benetin, Egon Kurča, Kathryn A. Wyman-Chick, Andrea Gažová, Ján Kyselovič, Peter Valkovič Bratislava Medical Journal.2025; 126(6): 1058. CrossRef - Adherence to Parkinson's disease medication: A case study to illustrate reasons for non-adherence, implications for practice and engaging under-represented participants in research
Delyth James, Joshua Smith, Emma Lane, Rhian Thomas, Sarah Brown, Heidi Seage Exploratory Research in Clinical and Social Pharmacy.2024; 14: 100450. CrossRef - Relationship Between Medication Literacy and Beliefs Among Persons with Type 2 Diabetes Mellitus in Guangdong, China
Sifen Jiang, Zhuoqi Zhu, Guisheng Liao, Yanling Huang, Lichang Li, Kun Zeng Patient Preference and Adherence.2023; Volume 17: 2039. CrossRef - Effect of Pillbox Organizers with Alarms on Adherence to Pharmacotherapy in Parkinson Disease Patients Taking Three and More Daily Doses of Dopaminergic Medications
Igor Straka, Michal Minar, Milan Grofik, Matej Skorvanek, Veronika Bolekova, Andrea Gazova, Jan Kyselovic, Peter Valkovic Journal of Personalized Medicine.2022; 12(2): 179. CrossRef - Factors Related to Beliefs about Medication in Ischemic Stroke Patients
Gye-Gyoung Kim, Sung-Hee Yoo, Man-Seok Park, Hyun-Young Park, Jae-Kwan Cha Journal of Clinical Medicine.2022; 11(13): 3825. CrossRef - Lycium barbarum polysaccharide improves dopamine metabolism and symptoms in an MPTP-induced model of Parkinson’s disease
Jiangbo Song, Lian Liu, Zhiquan Li, Ting Mao, Jianfei Zhang, Lei Zhou, Xin Chen, Yunzhu Shang, Tao Sun, Yuxin Luo, Yu Jiang, Duan Tan, Xiaoling Tong, Fangyin Dai BMC Medicine.2022;[Epub] CrossRef
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