Journal of Movement Disorders

Hae-Won Shin

5 Articles

Mosapride-Induced Movement Disorders: Sang-Wook Hong, Hae-Won Shin; J Mov Disord. 2022;15(3):273-276. Published online May 10, 2022; DOI: https://doi.org/10.14802/jmd.21149

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Long-term Effects of Bilateral Subthalamic Deep Brain Stimulation on Postural Instability and Gait Difficulty in Patients with Parkinson’s Disease: Hae-Won Shin, Mi Sun Kim, Sung Reul Kim, Sang Ryong Jeon, Sun Ju Chung; J Mov Disord. 2020;13(2):127-132. Published online May 29, 2020; DOI: https://doi.org/10.14802/jmd.19081

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Objective
The long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on postural instability and gait difficulty (PIGD) in patients with Parkinson’s disease (PD) remain unclear. In this study, we aimed to evaluate the longterm effects of STN-DBS surgery on PIGD symptoms in patients with advanced-stage PD. Methods This study included 49 consecutively included patients with PD who underwent bilateral STN-DBS. The Unified Parkinson’s Disease Rating Scale (UPDRS) scores and subscores for PIGD were assessed at baseline and at 1, 3, and 5 years postoperatively. The PIGD subscore was divided into PIGD-motor and PIGD-activities of daily living (ADL) scores according to parts III and II of the UPDRS, respectively. Results The PIGD-motor and PIGD-ADL scores at the “medication-off” state improved at 3 and 5 years, respectively. Overall, the UPDRS III and II scores at “medication-off” improved at 5 years. The UPDRS IV score also significantly improved and the levodopa equivalent daily dosage decreased at all follow-ups. Finally, the PIGD-motor score at baseline was able to predict long-term improvement in the PIGD-motor score at the 5-year follow-up. Conclusion The STN-DBS has both short- and long-term effects on PIGD, as well as overall motor function, in patients with advanced PD. The degree of PIGD at the preoperative evaluation can be used to predict long-term outcomes after STN-DBS surgery.

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Long-term motor outcomes of deep brain stimulation of the globus pallidus interna in Parkinson's disease patients: Five-year follow-up
Yun Su Hwang, Sungyang Jo, Seung Hyun Lee, Nayoung Kim, Mi-Sun Kim, Sang Ryong Jeon, Sun Ju Chung
Journal of the Neurological Sciences.2023; 444: 120484. CrossRef
The Role of Microelectrode Recording in Deep Brain Stimulation Surgery for Parkinson’s Disease: A Systematic Review and Meta-Analysis
R. Saman Vinke, Martin Geerlings, Ashok K. Selvaraj, Dejan Georgiev, Bastiaan R. Bloem, Rianne A.J. Esselink, Ronald H.M.A. Bartels
Journal of Parkinson's Disease.2022; 12(7): 2059. CrossRef
Axial impairment and falls in Parkinson’s disease: 15 years of subthalamic deep brain stimulation
Alessandro Zampogna, Francesco Cavallieri, Francesco Bove, Antonio Suppa, Anna Castrioto, Sara Meoni, Pierre Pélissier, Emmanuelle Schmitt, Amélie Bichon, Eugénie Lhommée, Andrea Kistner, Stephan Chabardès, Eric Seigneuret, Valerie Fraix, Elena Moro
npj Parkinson's Disease.2022;[Epub] CrossRef

Multifocal Myoclonus as a Manifestation of Acute Cerebral Infarction Recovered by Carotid Arterial Stenting: Hyangkyoung Kim, Jun Soo Byun, Mark Hallett, Hae-Won Shin; J Mov Disord. 2017;10(1):64-66. Published online January 18, 2017; DOI: https://doi.org/10.14802/jmd.16040

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Movement Disorders Associated With Cerebral Artery Stenosis: A Nationwide Study
Kye Won Park, Nari Choi, Eungseok Oh, Chul Hyoung Lyoo, Min Seok Baek, Han-Joon Kim, Dalla Yoo, Jee-Young Lee, Ji-Hyun Choi, Jae Hyeok Lee, Seong-Beom Koh, Young Hee Sung, Jin Whan Cho, Hui-Jun Yang, Jinse Park, Hae-Won Shin, Tae-Beom Ahn, Ho-Sung Ryu, So
Frontiers in Neurology.2022;[Epub] CrossRef

Hyperhomocysteinemia in Patients with Parkinson’s Disease and Relationship to Vitamin B Level: Hae-Won Shin, Young Ho Sohn; J Mov Disord. 2009;2(1):33-36.; DOI: https://doi.org/10.14802/jmd.09008

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Abstract PDF

Background:

Plasma homocysteine (Hcy) levels are increased in patients with Parkinson’s disease (PD) undergoing levodopa treatment. We measured the Hcy levels in PD patients and assessed the relationship between Hcy level and features of PD, cognitive function and vitamin B status.

Methods:

Concentrations of Hcy, vitamin B₁₂ and folate were measured in 33 PD patients and 41 normal control individuals. Mini-mental Status Examination (MMSE) was assessed in all subjects. In PD patients, Hoehn & Yahr stage and Unified Parkinson Disease Rating Scale (UPDRS) motor scores were also examined.

Results:

Plasma Hcy levels were lower in PD patients than in control individuals. Hcy level was inversely correlated with vitamin B₁₂ and folate levels in the PD group but not in control individuals. Age, symptom duration, UPDRS motor scores, MMSE score, levodopa dose and duration of treatment did not differ between patients with Hcy >14 μmol/L and those with Hcy <14 μmol/L.

Conclusions:

Plasma Hcy levels were increased in PD patients with levodopa treatment and were related to vitamin B level. These results indicate that vitamin supplementation may be beneficial in levodopa-treated PD patients, although hyperhomocysteinemia did not affect the motor and cognitive status of PD patients.

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An umbrella review of systematic reviews with meta-analysis on the role of vitamins in Parkinson’s disease
Sama Rahnemayan, Sasan Ghazanfar Ahari, Reza Rikhtegar, Sevda Riyahifar, Sarvin Sanaie
Acta Neurologica Belgica.2023; 123(1): 69. CrossRef
Large-Fiber Neuropathy in Parkinson’s Disease: Clinical, Biological, and Electroneurographic Assessment of a Romanian Cohort
Oana Maria Vanta, Nicoleta Tohanean, Sebastian Pintea, Lacramioara Perju-Dumbrava
Journal of Clinical Medicine.2019; 8(10): 1533. CrossRef
Parkinson's disease, hyperhomocysteinemia and thrombosis: A dangerous combination
S. Bellakhal, E. Gharbi, Z. Meddeb, M. Mrouki, I. Abdelkéfi, M.-H. Douggui
Revue Neurologique.2016; 172(6-7): 398. CrossRef
Associations between B Vitamins and Parkinson’s Disease
Liang Shen
Nutrients.2015; 7(9): 7197. CrossRef

Chorea as an Initial Manifestation of Polycythemia Vera: Ji Eun Lee, Hae-Won Shin, Young H. Sohn; J Mov Disord. 2008;1(2):82-85.; DOI: https://doi.org/10.14802/jmd.08015

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Abstract PDF: Chorea is a rare complication of polycythemia vera (PV). We report a 58-year-old woman with acute onset chorea without structural lesion in the basal ganglia. The physical and laboratory findings were compatible with the diagnosis of PV. After repeated phlebotomies her chorea was improved. PV should be considered as one of the possible etiologies of chorea, as early diagnosis is important to lead to the effective treatment and prevention of complications.

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