- The Impact of Impulsivity on Quality of Life in Early Drug-Naïve Parkinson’s Disease Patients
-
Dong-Woo Ryu, Joong-Seok Kim, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee
-
J Mov Disord. 2019;12(3):172-176. Published online August 9, 2019
-
DOI: https://doi.org/10.14802/jmd.19004
-
Correction in: J Mov Disord 2021;14(2):176
-
4,399
View
-
104
Download
-
4
Citations
-
 Abstract
 PDF
- Objective
Impulse control disorders (ICDs) in Parkinson’s disease (PD) are mostly related to dopamine replacement therapy (DRT); however, drug-naïve PD patients have also frequently experienced impulsivity. This phenomenon makes clinicians hesitate treating patients with DRT. In this study, we assessed the effect of impulsivity on quality of life (QOL) in drug-naïve PD patients.
Methods
Two hundred three newly diagnosed, nonmedicated PD patients were enrolled, and they received structured clinical interviews, physical examinations and validated questionnaires to evaluate motor and nonmotor symptoms and QOL. Impulsivity was evaluated using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale (QUIP-RS).
Results
Thirty-eight patients (18.7%) had impulsivity with QUIP-RS scores ≥ 1 and 4 patients (2.0%) were diagnosed with combined ICDs. Motor and nonmotor symptoms were significantly correlated with the Parkinson’s Disease Questionnaire-39 summary index. Female sex and QUIP-RS scores were also correlated with QOL in drug-naïve PD patients.
Conclusion
The results of the present study showed that impulsivity negatively influences QOL in early drug-naïve PD patients. In addition, more severe motor and nonmotor symptoms were also associated with lower QOL. Such findings complicate treatment but provide valuable information for managing early PD.
-
Citations
Citations to this article as recorded by  - Neuropsychiatric Symptoms in Parkinson's Disease After Subthalamic Nucleus Deep Brain Stimulation
Weibing Liu, Tatsuya Yamamoto, Yoshitaka Yamanaka, Masato Asahina, Tomoyuki Uchiyama, Shigeki Hirano, Keisuke Shimizu, Yoshinori Higuchi, Satoshi Kuwabara
Frontiers in Neurology.2021;[Epub] CrossRef - Dopamine genetic risk score predicts impulse control behaviors in Parkinson’s disease
Alison Hall, Samuel R. Weaver, Lindsey J. Compton, Winston D. Byblow, Ned Jenkinson, Hayley J. MacDonald
Clinical Parkinsonism & Related Disorders.2021; 5: 100113. CrossRef - A Review of the Concept of Impulsivity
Mohammed Munther Al-Hammouri, Jehad A. Rababah, Celeste Shawler
Advances in Nursing Science.2021; 44(4): 357. CrossRef - Assessment of therapeutic strategies for management of impulse control disorder in Parkinson’s disease
Mayela Rodríguez-Violante, Yazmín Ríos-Solís, Oscar Esquivel-Zapata, Fanny Herrera, Susana López-Alamillo, Cynthia Sarabia-Tapia, Amin Cervantes-Arriaga
Arquivos de Neuro-Psiquiatria.2021; 79(11): 989. CrossRef
- Camptocormia with Transient Ischemic Attack
-
Ju-Hee Oh, Dong-Woo Ryu, Si-Hoon Lee, Joong-Seok Kim
-
J Mov Disord. 2017;10(1):62-63. Published online January 18, 2017
-
DOI: https://doi.org/10.14802/jmd.16043
-
-
6,375
View
-
83
Download
-
2
Citations
-
PDF
-
Citations
Citations to this article as recorded by - Mesial Frontal Lobe Infarction Presenting as Pisa Syndrome
Kazuyuki Noda, Maya Ando, Takayuki Jo, Anri Hattori, Kotaro Ogaki, Mizuho Sugiyama, Nobutaka Hattori, Yasuyuki Okuma
Journal of Stroke and Cerebrovascular Diseases.2020; 29(8): 104882. CrossRef - Transient camptocormia with citalopram treatment in a patient with mixed dementia–A case report
Segal Inbal, RN Galia Fisher, Merims Doron
Archive of Gerontology and Geriatrics Research.2020; : 040. CrossRef
|
KMDS
E-submission
