Journal of Movement Disorders

Beom S. Jeon

5 Articles

Nonmotor Symptoms and Subthalamic Deep Brain Stimulation in Parkinson’s Disease: Han-Joon Kim, Beom S. Jeon, Sun Ha Paek; J Mov Disord. 2015;8(2):83-91. Published online May 31, 2015; DOI: https://doi.org/10.14802/jmd.15010

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Subthalamic deep brain stimulation (STN DBS) is an established treatment for the motor symptoms in patients with advanced Parkinson’s disease (PD). In addition to improvements in motor symptoms, many studies have reported changes in various nonmotor symptoms (NMSs) after STN DBS in patients with PD. Psychiatric symptoms, including depression, apathy, anxiety, and impulsivity, can worsen or improve depending on the electrical stimulation parameters, the locations of the stimulating contacts within the STN, and changes in medications after surgery. Global cognitive function is not affected by STN DBS, and there is no increase in the incidence of dementia after STN DBS compared to that after medical treatment, although clinically insignificant declines in verbal fluency have been consistently reported. Pain, especially PD-related pain, improves with STN DBS. Evidence regarding the effects of STN DBS on autonomic symptoms and sleep-related problems is limited and remains conflicting. Many symptoms of nonmotor fluctuations, which are occasionally more troublesome than motor fluctuations, improve with STN DBS. Although it is clear that NMSs are not target symptoms for STN DBS, NMSs have a strong influence on the quality of life of patients with PD, and clinicians should thus be aware of these NMSs when deciding whether to perform surgery and should pay attention to changes in these symptoms after STN DBS to ensure the optimal care for patients.

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Stiff-Person Syndrome: Case Series: Yu Jin Jung, Han G. Jeong, Ryul Kim, Han-Joon Kim, Beom S. Jeon; J Mov Disord. 2014;7(1):19-21. Published online April 30, 2014; DOI: https://doi.org/10.14802/jmd.14004

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Abstract PDF

Stiff-person syndrome (SPS) is a rare disorder, characterized by progressive fluctuating muscular rigidity and spasms. Glutamic acid decarboxylase (GAD) antibody is primarily involved in the pathogenesis of SPS and SPS is strongly associated with other autoimmune disease. Here we report three cases of patients with classical SPS finally confirmed by high serum level of GAD antibodies. All of our patients respond favorably to gamma amino butyric acid-enhancing drugs and immunotherapies.

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Stiff Person Syndrome in a patient with atypical carcinoid tumor of the lung secondary to anti-amphiphysin antibodies: A case report and literature review
Khawla Abusamra, Mangayarkarasi Thandampallayam, Douglas Lukins, Padmaja Sudhakar
Neuroimmunology Reports.2022; 2: 100116. CrossRef
Efficacy and safety of therapeutic plasma exchange in stiff person syndrome
Piotr F. Czempik, Justyna Gawryluk, Agnieszka Wiórek, Ewa Krzystanek, Łukasz J. Krzych
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Amantadine Induced Corneal Edema in a Patient with Primary Progressive Freezing of Gait: Young Eun Kim, Ji Young Yun, Hui-Jun Yang, Han-Joon Kim, Mee Kum Kim, Won Ryang Wee, Beom S. Jeon; J Mov Disord. 2013;6(2):34-36. Published online October 30, 2013; DOI: https://doi.org/10.14802/jmd.13008

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6 Citations

Abstract PDF

Amantadine is commonly used for Parkinsonism. However amantadine can induce adverse corneal reaction. Here we report a patient with primary progressive freezing of gait who had severe corneal edema associated with amantadine, which was reversible after discontinuation of the amantadine. This report alerts neurologists for this reversible but potentially critical corneal edema in patients with Parkinsonism who are receiving amantadine.

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Parkinson’s disease between internal medicine and neurology
Ilona Csoti, Wolfgang H. Jost, Heinz Reichmann
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Amantadine Use as a Risk Factor for Corneal Edema: A Nationwide Cohort Study in Taiwan
Po Yen Lee, Hung Pin Tu, Chang Ping Lin, Cheng Hsien Chang, Kai Chun Cheng, Chia Ching Lin, Shiuh Liang Hsu
American Journal of Ophthalmology.2016; 171: 122. CrossRef

Hypomania Induced by Subthalamic Nucleus Stimulation in a Parkinson’s Disease Patient: Does It Suggest a Dysfunction of the Limbic Circuit?: Ji Seon Kim, Hee Jin Kim, Ji-Young Lee, Jong Min Kim, Ji Young Yun, Beom S. Jeon; J Mov Disord. 2012;5(1):14-17.; DOI: https://doi.org/10.14802/jmd.12004

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6 Citations

Abstract PDF

The aim of this report was to describe a case of hypomania after deep brain stimulation of the subthalamic nucleus (STN DBS) in a Parkinson’s disease (PD) patient. 59-year-old man with a 15-year history of PD underwent bilateral implantation of electrodes to the STN. Immediately after surgery, his motor function was markedly improved and his mood was elevated to hypomania. Fusion images of the preoperative MRI and postoperative CT scan showed that the electrodes were located in the medial portion of the STN. In this case, behavioral mood change was related to the deep brain stimulation. Moreover, the anatomical location and the functional alteration of the STN after the DBS surgery might be related to the regulatory system of the associative and limbic cortico-subcortical circuits.

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Clara Lo, Mansee Mane, Jee Hyun Kim, Michael Berk, Richard R. Sharp, Kendall H. Lee, Jason Yuen
International Journal of Drug Policy.2023; 113: 103964. CrossRef
The anatomo-functional organization of the hyperdirect cortical pathway to the subthalamic area using in vivo structural connectivity imaging in humans
Gizem Temiz, Sophie B. Sébille, Chantal Francois, Eric Bardinet, Carine Karachi
Brain Structure and Function.2020; 225(2): 551. CrossRef
Hypomania and saccadic changes in Parkinson’s disease: influence of D2 and D3 dopaminergic signalling
Esther A. Pelzer, Barbara Dillenburger, Sophie Grundmann, Vladimir Iliaev, Sophie Aschenberg, Corina Melzer, Martin Hess, Gereon R. Fink, Carsten Eggers, Marc Tittgemeyer, Lars Timmermann
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Overlapping and distinct neural metabolic patterns related to impulsivity and hypomania in Parkinson’s disease
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Affective modulation of the associative-limbic subthalamic nucleus: deep brain stimulation in obsessive–compulsive disorder
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Translational Psychiatry.2019;[Epub] CrossRef
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Adult Onset Familial Cherry-Red Spot Myoclonus: Chi Kyung Kim, Beom S. Jeon; J Mov Disord. 2009;2(1):50-52.; DOI: https://doi.org/10.14802/jmd.09014

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Abstract PDF: We report a case of a 36-year-old woman with progressive generalized myoclonus that first became apparent 9 years ago. Her younger brother had similar problems. Examination of her eyes revealed cherry-red spots. Hexosaminidase A, β-galactosidase and neuraminidase activity were normal. Although the laboratory findings were negative, cherry-red spots, progressive myoclonus and autosomal recessive inheritance pattern suggested that she had an unknown type of lysosomal storage disease.

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